Abstract Regulation of global transcription output is important for normal development and disease, but little is known about the mechanisms involved.DNA topoisomerase I (TOP1) is an enzyme well-known for its role in relieving DNA supercoils for enabling transcription.Here, we report a non-enzymatic function of TOP1 that downregulates RNA synthesis
Abstract Background Hypoxia has been shown to be able to induce tenogenic differentiation and proliferation of mesenchymal stem cells (MSCs) which lead hypoxia-induced MSCs to be a potential treatment for tendon injury.However, little is known about the mechanism underlying the tenogenic differentiation and proliferation process of hypoxic MSCs, wh
I wrote this article during Koozies the summer of 2001 in order to present it at the III National Conference of Military Nursing held in Cartagena in April 2002.Although written nearly a year ago, last November governmental decisions with regard to nursing career development come to show little quantitative or qualitative change; on the contrary, t
Additive manufacturing in the field of tissue engineering has evolved rapidly over the past few decades.3D bioprinting is an extended application of additive manufacturing that involves the building of tissue or organ in a layer-by-layer manner using a bioprinter via instructions from computer graphic software.3D bioprinting technology offers promi
The usage of Information, Communication and Technology (ICT) in health sector has a great potential in improving the health of individuals and communities, disease detection, prevention and overall strengthening the healthcare systems, vital for development and poverty reduction.Large ICT establishments offer a variety of Artificial Intelligence (A